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Free Medical Coding > ICD10 CM > 2025 ICD-10-CM Codes > 2025 ICD-10-CM Codes I00-I99 – Diseases of the circulatory system (I00-I99) > 2025 ICD-10-CM Codes I20-I25 – Ischemic heart diseases (I20-I25) > 2025 ICD-10-CM Codes I21 – Acute myocardial infarction (I21) > 2025 ICD-10-CM Diagnosis Code I21.4 – Non-ST elevation (NSTEMI) myocardial infarction (I21.4)

2025 ICD-10-CM Diagnosis Code I21.4 – Non-ST elevation (NSTEMI) myocardial infarction (I21.4)

2016201720182019202020212022202320242025Billable/Specific Code
  • I21.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM I21.4 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of I21.4 – other international versions of ICD-10 I21.4 may differ.

ICD-10-CM I21.4 is grouped within Diagnostic Related Group(s):

  • 222 Cardiac defibrillator implant with cardiac catheterization with ami, hf or shock with mcc
  • 223 Cardiac defibrillator implant with cardiac catheterization with ami, hf or shock without mcc
  • 280 Acute myocardial infarction, discharged alive with mcc
  • 281 Acute myocardial infarction, discharged alive with cc
  • 282 Acute myocardial infarction, discharged alive without cc/mcc
  • 283 Acute myocardial infarction, expired with mcc
  • 284 Acute myocardial infarction, expired with cc
  • 285 Acute myocardial infarction, expired without cc/mcc

Applicable To

  • Acute subendocardial myocardial infarction
  • Non-Q wave myocardial infarction NOS
  • Nontransmural myocardial infarction NOS
  • Type 1 non-ST elevation myocardial infarction

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2016 (effective 10/1/2015): No change
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to I21.4:

  • non-Q wave > myocardium, myocardial (acute) (with stated duration of 4 weeks or less) I21.9
  • non-ST elevation (NSTEMI) > myocardium, myocardial (acute) (with stated duration of 4 weeks or less) I21.9
  • nontransmural > myocardium, myocardial (acute) (with stated duration of 4 weeks or less) I21.9
  • nontransmural > Infarct, infarction
  • subendocardial (acute) (nontransmural) > Infarct, infarction
  • subendocardial (acute) > Necrosis, necrotic (ischemic)

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