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Free Medical Coding > ICD10 CM > 2025 ICD-10-CM Codes > 2025 ICD-10-CM Codes E00-E89 – Endocrine, nutritional and metabolic diseases (E00-E89) > 2025 ICD-10-CM Codes E70-E88 – Metabolic disorders (E70-E88) > 2025 ICD-10-CM Codes E85 – Amyloidosis (E85) > 2025 ICD-10-CM Diagnosis Code E85.4 – Organ-limited amyloidosis (E85.4)

2025 ICD-10-CM Diagnosis Code E85.4 – Organ-limited amyloidosis (E85.4)

2016201720182019202020212022202320242025Billable/Specific Code
  • E85.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM E85.4 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of E85.4 – other international versions of ICD-10 E85.4 may differ.

ICD-10-CM E85.4 is grouped within Diagnostic Related Group(s):

  • 545 Connective tissue disorders with mcc
  • 546 Connective tissue disorders with cc
  • 547 Connective tissue disorders without cc/mcc

Applicable To

  • Localized amyloidosis
  • Transthyretin-related (ATTR) familial amyloid cardiomyopathy

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2016 (effective 10/1/2015): No change
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to E85.4:

  • with lung involvement > Amyloidosis (generalized) (primary) E85.9
  • heart > Amyloidosis (generalized) (primary) E85.9
  • liver > Amyloidosis (generalized) (primary) E85.9
  • localized > Amyloidosis (generalized) (primary) E85.9
  • organ limited > Amyloidosis (generalized) (primary) E85.9
  • pulmonary > Amyloidosis (generalized) (primary) E85.9
  • skin (lichen) (macular) > Amyloidosis (generalized) (primary) E85.9
  • subglottic > Amyloidosis (generalized) (primary) E85.9
  • amyloid > cerebral I67.9
  • amyloidosis > in (due to) E22.0
  • amyloidosis > in (due to) E22.0
  • amyloid > Cardiomyopathy (familial) (idiopathic) I42.9
  • transthyretin-related familial (ATTR) > amyloid E85.4
  • transthyretin-related familial amyloid (ATTR) > Cardiomyopathy (familial) (idiopathic) I42.9
  • artery, arterial (atheromatous) (calcareous) > Degeneration, degenerative
  • cerebral, amyloid > artery, arterial (atheromatous) (calcareous) E85.4
  • amyloid > cutis L98.8
  • heart > Degeneration, degenerative
  • amyloid > heart E85.4
  • intestine, amyloid > Degeneration, degenerative
  • amyloid > kidney N28.89
  • amyloid > liver NEC (diffuse) K76.89
  • amyloid > nervous system G31.9
  • amyloid > skin L98.8
  • amyloid > spinal (cord) G31.89
  • amyloid > spleen D73.0
  • amyloid > gastrointestinal (tract) K92.9
  • amyloid > heart (organic) I51.9
  • in > lung J98.4
  • amyloidosis > in E85.4
  • amyloid > spleen D73.9
  • amyloidosis > glomerular (in) N05.9
  • in (due to) > Glaucoma H40.9
  • amyloidosis > in (due to) E85.4
  • in (due to) > Glomerulonephritis N05.9
  • amyloidosis > in (due to) E85.4
  • amyloidosis > Lichen L28.0
  • amyloid > Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
  • in > Nephrosis, nephrotic (Epstein\’s) (syndrome) (congenital) N04.9
  • amyloidosis > in E85.4
  • amyloid, any site > Neuritis (rheumatoid) M79.2
  • in (due to) > autonomic G90.9
  • amyloidosis > in (due to) E85.4

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