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Free Medical Coding > ICD10 CM > 2025 ICD-10-CM Codes > 2025 ICD-10-CM Codes E00-E89 – Endocrine, nutritional and metabolic diseases (E00-E89) > 2025 ICD-10-CM Codes E00-E07 – Disorders of thyroid gland (E00-E07) > 2025 ICD-10-CM Codes E05 – Thyrotoxicosis [hyperthyroidism] (E05) > 2025 ICD-10-CM Codes E05.2 – Thyrotoxicosis with toxic multinodular goiter (E05.2) > 2025 ICD-10-CM Diagnosis Code E05.21 – Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm (E05.21)

2025 ICD-10-CM Diagnosis Code E05.21 – Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm (E05.21)

2016201720182019202020212022202320242025Billable/Specific Code
  • E05.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM E05.21 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of E05.21 – other international versions of ICD-10 E05.21 may differ.

ICD-10-CM E05.21 is grouped within Diagnostic Related Group(s):

  • 011 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with mcc
  • 012 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with cc
  • 013 Tracheostomy for face, mouth and neck diagnoses or laryngectomy without cc/mcc
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2016 (effective 10/1/2015): No change
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to E05.21:

  • with thyroid storm > toxic or with hyperthyroidism E05.20
  • with thyroid storm > hyperthyroidism E05.20
  • with thyroid storm > thyrotoxicosis E05.20
  • with thyroid storm > toxic E05.20
  • with thyroid storm > nodular (multinodular) E05.20
  • with thyroid storm > with thyrotoxicosis E05.20
  • with thyroid storm > toxic or with hyperthyroidism E05.20
  • with thyroid storm > Plummer\’s disease E05.20
  • with thyroid storm > toxic or with hyperthyroidism E05.20
  • with thyroid storm > multinodular E05.20
  • with thyroid storm > toxicosa E05.20
  • with thyroid storm > multinodular E05.20
  • with thyroid storm > multinodular E05.20
  • with thyroid storm > nodular E05.20

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