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Free Medical Coding > ICD10 CM > 2025 ICD-10-CM Codes > 2025 ICD-10-CM Codes D50-D89 – Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) > 2025 ICD-10-CM Codes D80-D89 – Certain disorders involving the immune mechanism (D80-D89) > 2025 ICD-10-CM Codes D80 – Immunodeficiency with predominantly antibody defects (D80) > 2025 ICD-10-CM Diagnosis Code D80.1 – Nonfamilial hypogammaglobulinemia (D80.1)

2025 ICD-10-CM Diagnosis Code D80.1 – Nonfamilial hypogammaglobulinemia (D80.1)

2016201720182019202020212022202320242025Billable/Specific Code
  • D80.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM D80.1 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of D80.1 – other international versions of ICD-10 D80.1 may differ.

ICD-10-CM D80.1 is grouped within Diagnostic Related Group(s):

  • 814 Reticuloendothelial and immunity disorders with mcc
  • 815 Reticuloendothelial and immunity disorders with cc
  • 816 Reticuloendothelial and immunity disorders without cc/mcc

Applicable To

  • Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
  • Common variable agammaglobulinemia [CVAgamma]
  • Hypogammaglobulinemia NOS

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2016 (effective 10/1/2015): No change
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to D80.1:

  • gamma globulin in blood > Absence (of) (organ or part) (complete or partial)
  • with > Agammaglobulinemia (acquired (secondary)) (nonfamilial) D80.1
  • immunoglobulin-bearing B-lymphocytes > with D80.1
  • common variable (CVAgamma) > Agammaglobulinemia (acquired (secondary)) (nonfamilial) D80.1
  • hypogammaglobulinemia > in (due to) E22.0
  • gammaglobulin in blood > Deficiency, deficient
  • in (due to) > connective tissue, systemic (diffuse) M35.9
  • hypogammaglobulinemia > in (due to) D80.1
  • nonfamilial > Hypogammaglobulinemia D80.1
  • agammaglobulinemic > antibody deficiency D80.9
  • hypogammaglobulinemic > antibody deficiency D80.9

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