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Free Medical Coding > ICD10 CM > 2025 ICD-10-CM Codes > 2025 ICD-10-CM Codes C00-D49 – Neoplasms (C00-D49) > 2025 ICD-10-CM Codes D37-D48 – Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48) > 2025 ICD-10-CM Codes D48 – Neoplasm of uncertain behavior of other and unspecified sites (D48) > 2025 ICD-10-CM Diagnosis Code D48.1 – Neoplasm of uncertain behavior of connective and other soft tissue (D48.1)

2025 ICD-10-CM Diagnosis Code D48.1 – Neoplasm of uncertain behavior of connective and other soft tissue (D48.1)

2016201720182019202020212022202320242025Billable/Specific Code
  • D48.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2024 edition of ICD-10-CM D48.1 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of D48.1 – other international versions of ICD-10 D48.1 may differ.

ICD-10-CM D48.1 is grouped within Diagnostic Related Group(s):

  • 564 Other musculoskeletal system and connective tissue diagnoses with mcc
  • 565 Other musculoskeletal system and connective tissue diagnoses with cc
  • 566 Other musculoskeletal system and connective tissue diagnoses without cc/mcc

Applicable To

  • Neoplasm of uncertain behavior of connective tissue of ear
  • Neoplasm of uncertain behavior of connective tissue of eyelid
  • Stromal tumors of uncertain behavior of digestive system

Type 1 Excludes

  • neoplasm of uncertain behavior of articular cartilage (D48.0)
  • neoplasm of uncertain behavior of cartilage of larynx (D38.0)
  • neoplasm of uncertain behavior of cartilage of nose (D38.5)
  • neoplasm of uncertain behavior of connective tissue of breast (D48.6-)

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2016 (effective 10/1/2015): No change
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to D48.1:

  • abdominal > Desmoid (extra-abdominal) (tumor)
  • gastric > stromal D39.0
  • uncertain behavior > gastric D48.1
  • uncertain behavior > gastrointestinal C49.A-
  • uncertain behavior > intestine D21.4
  • uncertain behavior > stomach C49.A2

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